Adult Stem Cells Decide the Fate of Their Daughters
The amount of the signaling protein Delta, shown in red, in an intestinal stem cell (ISC) determines the fate of its daughter cells. In panel A, an ISC that has just produced an enterocyte (EC) shows...
View ArticleH. Lee Moffitt Researchers Discover Potential Targets to Reduce Risk of Stem...
Inhibiting one gene -- even temporarily -- can improve cure rates for blood cancer patients who receive stem cell transplants. This strategy may also help patients with genetic and autoimmune diseases...
View ArticleBone Marrow Transplantation - Survival of AML patients receiving HLA-matched...
The reactivity of natural killer cells and some T-cell populations is regulated by killer immunoglobulintermterm-like receptors (KIR) interactions with target cell HLA class I molecules. Such...
View ArticleFunctional assessment and specific depletion of alloreactive human T cells...
Human T-cell alloreactivity plays an important role in many disease processes, including the rejection of solid organ grafts and graft-versus-host disease (GVHD) following allogeneic stem cell...
View ArticleCD25 expression on donor CD4+ or CD8+ T cells is associated with an...
Graft-versus-host disease (GVHD) occurs in an unpredictable fashion after 30% to 50% of matched-related transplantations. The presence of increased frequencies of CD4( )CD25( ) regulatory T cells in...
View ArticleEliciting cytotoxic T lymphocytes against acute myeloid leukemia-derived...
Dendritic cells (DC) have been successfully used in clinical pilot studies to induce tumor-specific immunity as well as clinical response in selected patients. However, DC-based immunotherapy remains...
View ArticleResearch shows cord blood comparable to matched bone marrow
University of Minnesota researchers report that umbilical cord blood transplants may offer blood cancer patients better outcomes than bone marrow transplants, according to an analysis of outcome data...
View ArticleHHMI News: Discovery in Fish May Aid Human Blood Cell Transplants
The discovery that zebrafish produce natural chemicals that enhance production of blood-forming stem cells may translate rapidly into new treatments to increase the success of bone marrow or cord...
View ArticleNew Cancer Treatment Adds to Survival Rates in Lung Cancer Patients
Patients with inoperable non-small cell lung cancer who receive an initial high dose of chemotherapyterm before their treatment begins can expect an increase in overall survival, according to a study...
View ArticleU of M begins nation's first clinical trial using T-reg cells from cord blood...
University of Minnesota researchers have initiated a ground breaking clinical trial to determine the optimal dose and safety of T regulatory cells (T-regs) to decrease the risk of immune reactions...
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